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Fibrinogen is a glycoprotein that has hemostatic and clotting effects and participates in the process of thrombosis, and also participates in the process of mediating inflammatory response. At present, the study on the relationship between fibrinogen, fibrinogen Bβ-455G/A gene polymorphism and ischemic stroke has attracted people′s attention, but there are few relevant reports, especially the study on the relationship between fibrinogen, fibrinogen Bβ-455G/A gene polymorphism and small-artery-occlusion cerebral infarction, and the conclusions are inconsistent. This paper reviews the recent studies on the correlation between fibrinogen, fibrinogen Bβ-455G/A gene polymorphism and ischemic stroke, mainly with small-artery-occlusion cerebral infarction.
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Objective@#To investigate the correlation between β-fibrinogen (FGB) gene -455G/A polymorphism and plasma fibrinogen (Fg) level and lacunar infarction (LI).@*Methods@#From June 2018 to August 2019, consecutive subjects without cerebrovascular disease and dementia admitted to the Department of Neurology, the People's Hospital of Liaoning Province were enrolled prospectively. According to whether there was LI or white matter hyperintensities (WMHs) in brain MRI, the patients were divided into LI group, LI+ WMHs group and control group. Polymerase chain reaction and gene sequencing technology were used to detect FGB -455G/A polymorphism. The turbidimetry was used to measure plasma Fg level. Multivariate logistic regression analysis was used to determine the independent risk factors for LI and LI+ WMHs.@*Results@#A total of 202 subjects were included, including 48 in the LI group, 58 in the LI+ WMHs group, and 96 in the control group. The proportions of patients with hypertension, dyslipidemia, and hyperhomocysteinemia and plasma Fg levels in the LI and LI+ WMHs groups were significantly higher than those in the control group (all P<0.05). There was no statistical difference in FGB -455G/A genotype and allele frequency between the three groups. The plasma Fg level of AG+ AA genotype was significantly higher than that of GG genotype (P<0.001), and there was no significant difference in demography and other vascular risk factors. Regardless of the genotype, the plasma Fg level was highest in the LI+ WMHs group, followed by the LI group and the control group, and the differences between each pair were statistically significant (P<0.05). Multivariate logistic regression analysis showed that hypertension (odds ratio [OR] 2.289, 95% confidence interval [CI] 1.015-5.166, P=0.046; OR 2.457, 95% CI 1.021-5.913, P=0.045), dyslipidemia (OR 2.681, 95% CI 1.217-5.905, P=0.014; OR 3.061, 95% CI 1.296-7.233, P=0.011) and plasma Fg levels (OR 5.038, 95% CI 2.328-10.902, P<0.001; OR 20.198, 95% CI 8.143-50.097, P<0.001) were all the independent risk factors for LI and LI+ WMHs.@*Conclusions@#The increased plasma Fg level, dyslipidemia, and hypertension were the independent risk factors for LI and LI+ WMHs. Although FGB -455G/A polymorphism could affect plasma Fg level, it had no significant correlation with LI and LI+ WMHs.
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Objective To study the relationships between androgen receptor (AR)expression and the clinicopathological features and prognosis of young patients (age≤35 years)with early-onset breast cancer in Xinjiang.Methods One hundred and forty-five young patients (age≤35 years)with invasive breast cancer who underwent surgery in Affiliated Cancer Hospital of of Xinjiang Medical University from January 201 0 to December 201 2 were collected.The expressions of AR in 1 45 patiens with early-onset breast cancer were detec-ted by immunohistochemical method.The relationships between AR expression and the clinicopathological fea-tures and prognosis of patients with early-onset breast cancer were retrospective analysed.Results The posi-tive rate of AR expression of patients with early-onset breast cancer in Xinjiang was 69.0% (1 00 /1 45).Single factor analysis showed that AR expression was related with neurovascular invasion (χ2 =5.309,P =0.021 ) and lymph node metastasis (χ2 =6.073,P =0.01 4),but it was not related with ethnicity (χ2 =0.097,P =0.755),age (χ2 =0.045,P =0.831 ),feeding history (χ2 =0.066,P =0.797),family history of cancer (P =0.556),histological grade (P =0.469),tumor size (χ2 =1 .006,P =0.605)and clinical stage (χ2 =4.381 ,P =0.223).The median follow-up time was 47 months.There was no significant difference between AR expression and disease-free survival of patients with early-onset breast cancer (χ2 =1 .972,P =0.1 60). Conclusion Early-onset breast cancer patients with AR positive are more likely to appear lymph node metasta-sis and neurovascular invasion than the patients with AR negative,which has certain guidance means for the treatment of early-onset breast cancer with lymph node metastasis positive.
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0 05). NSAIDs users were older than nonusers by a mean of 12 years, and more likely to have a history of upper gastrointestinal bleeding ( P =0 010) and cardiac vessel disease( P =0 000). NSAIDs users have higher number of ulcers ( P =0 002), fewer dyspeptic symptoms ( P =0 000) and shorter hospital stay( P =0 017).
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0.05).NSAIDs users were older than nonusers by a mean of 11 years, more likely to have a history of UGIG (P=0.002)and cardiac vessel disease(P=0.00 0).NSAIDs users have more number of ulcer or erosion(P=0.001)and fewer hospital stay(P=0.011). Conclusion Proper measures should be employed to decrease NSAIDs induced GI complications.
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Objective To compare the gastric mucosa damage induced by celecoxib and conventional NSAIDs——indomethacin. Methods NSAIDs induced gastric mucosal damage model in rats was obtained by pouring indomethacin, celecoxib respectively (n=8); After gastric damage induced by means of 100% ethanol, celecoxib were administered by gastric gavage (n=8). Gastric mucosal 6-keto-PGF 1? ,TXB 2 level and lesion index (LI) were measured. Morphological changes of gastric mucosa were assessed under light and scanning electronic microscopy. Results Indomethacin caused obvious gastric damage (LI:13.38?2.06) and a marked reduction of 6-keto-PGF 1? ,TXB 2 level was observed (P